The Fab of an antibody refers to the variable region and the first domain of the constant region. Antibodies have two while nanobodies have only one. They are sometimes used for biophysical studies and have been explored for therapeutic applications.
Observations
- Antibody fragments such as Fab regions are cleared more easily than full-lengths Abs (citation needed).
- Antibody fragments such as Fab regions can, when not glycosylated, be expressed in prokaryotes (citation needed).
- Fragments of Antibodies with only the Fab region can bypass the Lymphatic-system and penetrate deeper into tissues (citation needed).