Summary
A protein’s fold stability is more strongly correlated with its ability to refold after denaturing than its absolute melting temperature(1).
Figures
Ref(1)
1.
Wan Y, Liang J, Dai Y, Srinivasan K, Billesbølle C, Zhu J-F, et al. Hypervariable loop profiling decodes sequence determinants of antibody stability. Nature Structural & Molecular Biology. 2026 Apr; Available from: http://dx.doi.org/10.1038/s41594-026-01804-9