CDR1 and CDR2 contribute more to antibody stability than CDR3

Summary

An antibody’s CDR1 and CDR2 contribute more to overall fold stability than CDR3(1).

See also

• Fold stability is more strongly correlated with a protein’s ability to refold after denaturing than its melting temperature

1.

Wan Y, Liang J, Dai Y, Srinivasan K, Billesbølle C, Zhu J-F, et al. Hypervariable loop profiling decodes sequence determinants of antibody stability. Nature Structural & Molecular Biology. 2026 Apr; Available from: http://dx.doi.org/10.1038/s41594-026-01804-9