Summary
Free antibody light chains can form homodimers through paired VL/VL and CL/CL (1,2). The VL/VL interface resembles the VH/VL interface of an intact antibody, and a C-terminal disulfide can covalently link the homodimer (3,2).
1.
Rennella E, Morgan GJ, Kelly JW, Kay LE. Role of domain interactions in the aggregation of full-length immunoglobulin light chains. Proceedings of the National Academy of Sciences. 2018 Dec;116(3):854–63. Available from: https://doi.org/10.1073/pnas.1817538116
2.
Rottenaicher GJ, Absmeier RM, Meier L, Zacharias M, Buchner J. A constant domain mutation in a patient-derived antibody light chain reveals principles of AL amyloidosis. Communications Biology. 2023 Feb;6(1):209. Available from: https://doi.org/10.1038/s42003-023-04574-y
3.
Brumshtein B, Esswein SR, Landau M, Ryan CM, Whitelegge JP, Phillips ML, et al. Formation of Amyloid Fibers by Monomeric Light Chain Variable Domains. Journal of Biological Chemistry. 2014 Oct;289(40):27513–25. Available from: https://doi.org/10.1074/jbc.M114.585638