Quartz 4

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Interactions

Created Sep 26, 2026Modified Sep 07, 2026

Physical determinants of binding, specificity, interfaces, oligomerization, and assembly.

31 items with this tag.

Sep 25, 2026
De novo designed binders can have unbound ensembles that differ from the bound state
Sep 07, 2026
Free antibody light chains can homodimerize
- biophysics/interactions
Aug 25, 2026
A small number of high-energy hot spot interactions can dominate protein-protein binding energy
- biophysics/interactions
Aug 25, 2026
Antibodies often target cognate ligand epitopes without reproducing ligand contacts
- antibodies/recognition
- biophysics/interactions
Aug 19, 2026
Binding affinity of protein-protein interactions correlates with buried surface area
- biophysics/interactions
May 06, 2026
iPAE is anticorrelated with number of interface H-bonds
- prediction/confidence
- biophysics/interactions
Apr 28, 2026
Aromatic and polar residues make up disproportionate number of antigen epitopes
- antibodies/recognition
- biophysics/interactions
Apr 28, 2026
Dynamics and specificity are inversely related
- biophysics/dynamics
- biophysics/interactions
Apr 28, 2026
Subset of antigen residues contribute disproportionately to antibody binding affinity
- antibodies/recognition
- biophysics/interactions
Apr 21, 2026
Affinity maturation causes antibody-antigen interfaces to be more similar to generic PPI interfaces
Apr 21, 2026
Agonist antibodies benefit from low affinity due to antigen clustering
- cell-biology/therapeutic-mechanisms
- biophysics/interactions
Apr 21, 2026
Antibodies and BCRs have different binding kinetics
- biophysics/interactions
- cell-biology/immune-signaling
Apr 21, 2026
Antibody on and off rates are capped by the affinity maturation process
- antibodies/maturation
- biophysics/interactions
Apr 21, 2026
Arginines have a greater propensity to form protein-protein interactions than lysines
- biophysics/interactions
- evolution/selection
Apr 21, 2026
Biparatopic antibodies can induce clustering beyond what is observed in monoparatopic antibodies
- cell-biology/therapeutic-mechanisms
- biophysics/interactions
Apr 21, 2026
Effect of missense mutations on folding is greater than on binding
Apr 21, 2026
Homooligomeric proteins can undergo many stoichiometric changes in the course of evolution
- evolution/selection
- biophysics/interactions
Apr 21, 2026
Molecular glues
- cell-biology/therapeutic-mechanisms
- biophysics/interactions
Apr 21, 2026
Most homo-oligomeric complexes are symmetric
- biophysics/interactions
Apr 21, 2026
Protein abundance is inversely correlated with its propensity to form nonfunctional interactions
- evolution/selection
- biophysics/interactions
Apr 21, 2026
Protein-protein interaction interfaces are highly degenerate
- biophysics/interactions
Apr 21, 2026
Protein-protein interaction interfaces promote cotranslational assembly
- biophysics/interactions
- biophysics/folding
Apr 21, 2026
Protein-protein interfaces have looser packing than intra-chain interactions
- biophysics/interactions
Apr 21, 2026
Viral receptor-binding domains can bind the same receptor at different locations due to convergent evolution
- evolution/selection
- biophysics/interactions
Apr 21, 2026
Half of pathogenic mutations in intrinsically disordered regions improve binding to partners, or create new binding partners
- evolution/mutation-effects
- biophysics/interactions
Apr 21, 2026
Conformational entropy can decrease or increase following ligand binding
- biophysics/interactions
- biophysics/dynamics
Apr 21, 2026
Crystal structures can have nonphysiological salt bridges
- evidence/measurements
- biophysics/interactions
Apr 21, 2026
Insertion mutations are associated with gain-of-function
- evolution/mutation-effects
- biophysics/interactions
Apr 21, 2026
Protein dynamics can be used as filtering criteria for the design of highly selective small molecules
Apr 17, 2026
Heterodimerization domains
- design/modular-proteins
- biophysics/interactions
Apr 10, 2026
Protein-protein interactions
- biophysics/interactions

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