Summary
Germline precursors to high-affinity antibodies bind to their targets with 800 nM affinity on average (1). This was observed across twelve anti-SARS-CoV-2 public antibodies.
See also
1.
Kirby MB, Petersen BM, Faris JG, Kells SP, Sprenger KG, Whitehead TA. Retrospective SARS-CoV-2 human antibody development trajectories are largely sparse and permissive. Proceedings of the National Academy of Sciences. 2025;122(4). Available from: https://doi.org/10.1073/pnas.2412787122