Summary
Hallucination of complementarity-determining regions in antibodies using AlphaFold2 shows that every CDR except CDRH3 retains its original sequence at least a little (1).
1.
Ueki T, Ohue M. Antibody Complementarity-Determining Region Sequence Design Using AlphaFold2 and Binding Affinity Prediction Model. In: 2023 Congress in Computer Science, Computer Engineering, & Applied Computing (CSCE). IEEE; 2023. p. 2133–9. Available from: https://doi.org/10.1109/csce60160.2023.00350