Summary
Homo-oligomeric proteins can undergo many changes to stoichiometry in the course of evolution (1). This was observed across citrate synthases, which are functionally highly conserved by nonetheless observed to exist as dimers, hexamers, octamers, etc.
1.
Sendker FL, Schlotthauer T, Mais C-N, Lo YK, Girbig M, Bohn S, et al. Frequent transitions in self-assembly across the evolution of a central metabolic enzyme. Nature Communications. 2024;15(1). Available from: https://doi.org/10.1038/s41467-024-54408-6