Kemp eliminases are enzymes commonly used as a benchmark case in enzyme engineering and directed evolution campaigns.
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Ref (1)
1.
Otten R, Pádua RAP, Bunzel HA, Nguyen V, Pitsawong W, Patterson M, et al. How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science. 2020;370(6523):1442–6. Available from: https://doi.org/10.1126/science.abd3623