Summary
Positive charges on the CDRs of antibody light chains can reduce half-life by slowing release from FcRn (1). This was observed using biochemical assays and humanized mice.
Figures
Figure 3B from (1)
See also
Arginines have a greater propensity to form protein-protein interactions than lysines
1.
Schoch A, Kettenberger H, Mundigl O, Winter G, Engert J, Heinrich J, et al. Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics. Proceedings of the National Academy of Sciences. 2015;112(19):5997–6002. Available from: https://doi.org/10.1073/pnas.1408766112