Logistic regression outperforms fine-tuned LMs on finding point mutations from NGS data

Summary

Logistic regression outperforms fine-tunes PLMs on finding effective point mutations from NGS data (1).

Figures

Ref (1)

1.

Paul S, Harvey EP, Osei-Owusu J, Kollasch AW, Riesselman AJ, McMahon C, et al. Machine learning enables efficient and effective affinity maturation of nanobodies. openRxiv; 2026. Available from: https://doi.org/10.64898/2026.01.11.698911