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Directed evolution

Directed evolution

Created Sep 26, 2026Modified Sep 07, 2026

Iterative experimental optimization, library design, mutagenesis, selection, and model-guided experimental search.

25 items with this tag.

Aug 25, 2026
NGS sequence abundance does not correlate with binding affinity
- evidence/measurements
- design/directed-evolution
Jul 28, 2026
Directed evolution can uncover beneficial sequence modifications that might be missed by inverse folding
- design/directed-evolution
- design/inverse-folding
Jul 28, 2026
Directed evolution
- design/directed-evolution
Jul 28, 2026
Inverse folding selects more evolutionarily conserved design positions than sequence-only protein language models
Jul 28, 2026
Inverse-folding-guided site-saturation libraries outperform random mutagenesis
Jul 20, 2026
Uncrowded hypervolume improvement
- design/directed-evolution
- inference/sampling-and-search
Apr 21, 2026
Not all sequences with improved activity have plausible evolutionary paths via stepwise introduction of mutations
- evolution/mutation-effects
- design/directed-evolution
Apr 21, 2026
Affinity maturation of de novo minibinders introduces mutations far from the active site
- design/binders
- design/directed-evolution
Apr 21, 2026
Display methods
- design/directed-evolution
- evidence/measurements
Apr 21, 2026
Effectiveness of the BLOSUM62 for antibody affinity maturation varies by molecule
- design/antibodies
- design/directed-evolution
Apr 21, 2026
Highly thermostable sequences make better starting points to evolve new functions
Apr 21, 2026
Logistic regression outperforms fine-tuned LMs on finding point mutations from NGS data
- design/directed-evolution
- evidence/design-validation
Apr 21, 2026
ML improves directed evolution when navigating fitness landscapes with greater non-magnitude epistasis
- design/directed-evolution
- evolution/mutation-effects
Apr 21, 2026
ML optimized Ab libraries have more mutations than PSSM libraries
- design/antibodies
- design/directed-evolution
Apr 21, 2026
Most random mutants are nonfunctional
- evolution/mutation-effects
- design/directed-evolution
Apr 21, 2026
Search algorithms are more important than language model choice for model-guided protein engineering and design
- inference/sampling-and-search
- design/directed-evolution
Apr 21, 2026
Transporters can evolve specificity to new substrates with just a single mutation
- design/directed-evolution
- evolution/mutation-effects
Apr 21, 2026
CRISPR-Cas9
- design/directed-evolution
Apr 21, 2026
Accurate fitness landscapes are unnecessary for productively engineering enzymes or proteins
- design/directed-evolution
- evidence/design-validation
Apr 21, 2026
Fitness landscape navigability is correlated with its kurtosis and the centeredness of its maximum
- evolution/mutation-effects
- design/directed-evolution
Apr 21, 2026
Focused protein sequence libraries are poor training sets
- design/directed-evolution
- evidence/datasets
Apr 21, 2026
Functional proteins emerge from libraries of random sequences
- evolution/selection
- design/directed-evolution
Apr 20, 2026
Bayesian optimization
- design/directed-evolution
- inference/sampling-and-search
Apr 20, 2026
Helicase-assisted continuous editing
- design/directed-evolution
Apr 17, 2026
Protein engineering
- design/modular-proteins
- design/directed-evolution

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