Masking ESMFold can sometimes sample alternate conformations

Summary

Masking ESMFold can sometimes sample alternate conformations (1). However this only worked on a minority of tested proteins.

See also

• Randomly masking residues prior to running ESMFold allows false positives to be identified more effectively

1.

del Alamo D, Jeliazkov JR, Truan D, Karpiak JD. Conformational sampling and interpolation using language-based protein folding neural networks. openRxiv; 2023. Available from: https://doi.org/10.1101/2023.12.16.571997