Summary
Most commercial tool (antibodies) are nonspecific (1). This was assessed on over 1,100 antibodies available for sale for bench research (e.g., immunoprecipitation), which found that only 452 bound their targets with higher affinity than other targets.
1.
Marcon E, Jain H, Bhattacharya A, Guo H, Phanse S, Pu S, et al. Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation. Nature Methods. 2015;12(8):725–31. Available from: https://doi.org/10.1038/nmeth.3472