Summary
Most point mutations that antibodies obtain are the result of single-nucleotide changes. (1) noted that in the 51 somatic mutations observed across twelve antibodies against SARS-CoV-2, 47 (92%) were single-nucleotide changes.
1.
Kirby MB, Petersen BM, Faris JG, Kells SP, Sprenger KG, Whitehead TA. Retrospective SARS-CoV-2 human antibody development trajectories are largely sparse and permissive. Proceedings of the National Academy of Sciences. 2025;122(4). Available from: https://doi.org/10.1073/pnas.2412787122