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Mutation effects

Mutation effects

Created Sep 26, 2026Modified Sep 07, 2026

Biological effects of substitutions and indels, fitness landscapes, epistasis, and accessible evolutionary paths. Prediction algorithms go under prediction/variant-effects.

47 items with this tag.

May 06, 2026
Buried CDR residue mutations have similar effects on expression in other globular proteins
- design/developability
- evolution/mutation-effects
Apr 21, 2026
Mutations obtained by antibodies during affinity maturation show epistasis in biophysical properties but not binding
Apr 21, 2026
Not all sequences with improved activity have plausible evolutionary paths via stepwise introduction of mutations
- evolution/mutation-effects
- design/directed-evolution
Apr 21, 2026
Biophysical models trained on single and double point mutations can predict effects of three or more mutations on stability
Apr 21, 2026
DNA substitutions during somatic hypermutation are spatially clustered
- antibodies/maturation
- evolution/mutation-effects
Apr 21, 2026
Effect of missense mutations on folding is greater than on binding
Apr 21, 2026
Epistasis in antibodies during affinity maturation can be driven by CDR rearrangements
Apr 21, 2026
Epistasis in enzymes can arise from changes in the rate-limiting step of the catalytic cycle
- evolution/mutation-effects
- biophysics/catalysis
Apr 21, 2026
Epistasis is rare during evolution
- evolution/mutation-effects
- evolution/selection
Apr 21, 2026
Epistasis more likely to occur in buried residues than surface residues
- evolution/mutation-effects
- biophysics/stability
Apr 21, 2026
Fitness prediction
- prediction/variant-effects
- evolution/mutation-effects
Apr 21, 2026
Half of all disease-causing missense variants due to disruption of protein stability
Apr 21, 2026
Indels allows proteins to access phenotypes inaccessible to missense mutations
- evolution/mutation-effects
- evolution/selection
Apr 21, 2026
ML improves directed evolution when navigating fitness landscapes with greater non-magnitude epistasis
- design/directed-evolution
- evolution/mutation-effects
Apr 21, 2026
Missense mutation effects are predictive of effects of indels
- evolution/mutation-effects
- prediction/variant-effects
Apr 21, 2026
Most mutations with no effect on stability are found near the surface of proteins
- evolution/mutation-effects
- biophysics/stability
Apr 21, 2026
Most point mutations that antibodies obtain during affinity maturation are the result of single nucleotide changes
- antibodies/maturation
- evolution/mutation-effects
Apr 21, 2026
Most random mutants are nonfunctional
- evolution/mutation-effects
- design/directed-evolution
Apr 21, 2026
Mutation memory half life
- evolution/mutation-effects
Apr 21, 2026
Protein language models are able to predict epistasis in a zero-shot setting following a nonlinear transform
- prediction/variant-effects
- evolution/mutation-effects
Apr 21, 2026
Recessive genetic diseases more likely to be caused by protein destabilization than dominant genetic diseases
- evolution/mutation-effects
- biophysics/stability
Apr 21, 2026
Short insertions are common in evolution
- evolution/mutation-effects
- evolution/selection
Apr 21, 2026
Single deletion mutations are better tolerated than larger (2-3 residue) deletions
- evolution/mutation-effects
Apr 21, 2026
The majority of missense mutations are destabilizing
- evolution/mutation-effects
- biophysics/stability
Apr 21, 2026
Transporters can evolve specificity to new substrates with just a single mutation
- design/directed-evolution
- evolution/mutation-effects
Apr 21, 2026
Amino acid substitution patterns are dependent on solvent exposure
- evolution/mutation-effects
- evolution/selection
Apr 21, 2026
Amino acid substitution rates are rotamer-dependent
- evolution/mutation-effects
- evolution/selection
Apr 21, 2026
Half of pathogenic mutations in intrinsically disordered regions improve binding to partners, or create new binding partners
- evolution/mutation-effects
- biophysics/interactions
Apr 21, 2026
Fitness landscapes are locally smooth but globally rugged
- evolution/mutation-effects
Apr 21, 2026
Alpha-helices are more tolerant of mutations than beta-sheets
- evolution/mutation-effects
- biophysics/stability
Apr 21, 2026
Broadly neutralizing antibodies are more evolutionarily distant from germline sequences than less polyspecific antibodies
- antibodies/maturation
- evolution/mutation-effects
Apr 21, 2026
Conformational sampling can smoothen fitness landscapes
- evolution/mutation-effects
- biophysics/dynamics
Apr 21, 2026
Coupling strength of two substitutions is correlated with backbone distance
- evolution/mutation-effects
- biophysics/stability
Apr 21, 2026
Fitness landscape navigability is correlated with its kurtosis and the centeredness of its maximum
- evolution/mutation-effects
- design/directed-evolution
Apr 21, 2026
Indels better tolerated at termini
- evolution/mutation-effects
Apr 21, 2026
Insertion mutations are associated with gain-of-function
- evolution/mutation-effects
- biophysics/interactions
Apr 21, 2026
Insertions and deletions are more detrimental to stability than substitutions
- evolution/mutation-effects
- biophysics/stability
Apr 21, 2026
Insertions more tolerated than deletions
- evolution/mutation-effects
Apr 21, 2026
Mutations that give rise to new functions are not more destabilizing than mutations in general
- evolution/mutation-effects
- biophysics/stability
Apr 21, 2026
Natural selection favors the highest average local fitness
- evolution/selection
- evolution/mutation-effects
Apr 21, 2026
Neutral mutation frequency is similar across distance fitness peaks
- evolution/mutation-effects
Apr 21, 2026
Potts models and PSSMs can model fitness landscapes
- prediction/variant-effects
- evolution/mutation-effects
Apr 21, 2026
Second-shell mutations can yield positive epistasis
- evolution/mutation-effects
- design/enzymes
Apr 20, 2026
BLOSUM62
- evolution/homology
- evolution/mutation-effects
Apr 20, 2026
Evolution and natural selection
- evolution/selection
- evolution/mutation-effects
Apr 20, 2026
Epistasis
- evolution/mutation-effects
Apr 17, 2026
Potts models
- evolution/mutation-effects

Created with Quartz v4.5.2 © 2026

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