Multimodal sequence-structure guidance outperforms unimodal guidance in cases where both need to be designed

Summary

In cases where protein design requires both sequence and structure to be designed (such as disulfide design, or cation-$\pi$ design, simultaneous guidance of both sequence and structure outperforms guidance of just one modality at a time (1).

Figures

Ref (1)

1.

Rector-Brooks J, Lambert T, Skreta M, Roth D, Long Y, Li Z-Q, et al. General Multimodal Protein Design Enables DNA-Encoding of Chemistry. 2026; Available from: https://arxiv.org/abs/2604.05181