Engineering sequences, folds, binding, catalytic function, and properties that make proteins useful.
Engineering sequences, folds, binding, catalytic function, and properties that make proteins useful.
Computational antibody discovery, CDR design, and in-vitro or in-silico affinity optimization.
33 items with this tag.
Generating backbones, folds, and motif scaffolds; includes designability and structural-diversity limitations.
33 items with this tag.
Designing non-antibody protein binders and cross-format binder workflows; antibody-only work goes under design/antibodies.
10 items with this tag.
Expression, solubility, nonspecific binding, self-association, immunogenicity, humanization, and other constraints on making usable protein products.
49 items with this tag.
Iterative experimental optimization, library design, mutagenesis, selection, and model-guided experimental search.
25 items with this tag.
Engineering catalytic activity, enzyme specificity, active sites, and functional enzyme designs.
16 items with this tag.
Designing or scoring amino-acid sequences conditioned on a structure or structural ensemble; includes inverse-folding training and applications to property prediction.
55 items with this tag.
Domain insertion, fusion, oligomerization modules, and engineering proteins as structural or functional tools.
13 items with this tag.
Generating and optimizing sequences with sequence models, evolutionary profiles, or hallucination, including general sequence-search strategies. Fixed-structure sequence design goes under design/inverse-folding.
25 items with this tag.