Summary
The conformational dynamics of de novo designed proteins are easily influenced by mutations to nearby residues that don’t move (1) and by unpublished Kortemme lab results presented at NeurIPS 2023, as of 19 December 2023.
Figures
Slide from the Kortemme lab NeurIPS 2023 talk
See also
- Designed sequences of flexible proteins are dependent on conformation
- Modifying conformational landscapes of proteins can give rise to new functions
1.
Praetorius F, Leung PJY, Tessmer MH, Broerman A, Demakis C, Dishman AF, et al. Design of stimulus-responsive two-state hinge proteins. Science. 2023;381(6659):754–60. Available from: https://doi.org/10.1126/science.adg7731