Summary
Proteins designed by Inverse folding on one of two conformations occupy distinct parts of the sequence space. In the example below of gelsolin, sequence embeddings from ESM-1b are projected to a 2d space and compared to naturally occurring sequences. Only designs in one conformation overlap with naturally occurring sequences (left; (1)).
Figures
Ref (1)
1.
Mahajan SP, Dávila-Hernández FA, Ruffolo JA, Gray JJ. How well do contextual protein encodings learn structure, function, and evolutionary context? Cell Systems. 2025;16(3):101201. Available from: https://doi.org/10.1016/j.cels.2025.101201