Summary
Partial diffusion reduces the structural complexity of designed protein backbones (1). Running RF-diffusion on ProtPardelle designs led to greater helix/sheet character. It also converts sheets to helices, but not vice versa. Authors say “this behavior is valuable in design tasks which require engineering structural rigidity but could be a limitation in design tasks which require structural flexibility, such as engineering for allostery.”
Figures
Ref (1)
See also
- Partial structure diffusion can make de novo backbones more designable
- Sheets are less designable than helices
- Protein backbones designed using diffusion, but not sequence-based models, have fewer beta sheets
1.
Lu T, Liu M, Chen Y, Kim J, Huang P-S. Assessing generative model coverage of protein structures with SHAPES. Cell Systems. 2025;16(8):101347. Available from: https://doi.org/10.1016/j.cels.2025.101347