Sheets are less designable than helices

Summary

Beta-sheets are less designable than alpha helices using Inverse folding models (1). This was true for a range of models.

Figures

Design method	EHEE_3	EHEE_4	EHEE_5	EHEE_6	HHH_54	HHH_82	HHH_84	HHH_86	mean
GVP	0.158	0.285	0.299	0.271	0.682	0.593	0.588	0.658	0.442
PiFold	0.158	0.287	0.269	0.267	0.688	0.607	0.556	0.641	0.434
ProteinMPNN	0.176	0.282	0.314	0.274	0.688	0.584	0.570	0.626	0.439
ESMIF	0.171	0.335	0.331	0.282	0.678	0.660	0.625	0.691	0.472
ByProt	0.191	0.297	0.296	0.270	0.688	0.631	0.571	0.626	0.446
AF-Design	0.252	0.366	0.402	0.353	0.699	0.672	0.661	0.723	0.516
ESM-Design	0.153	0.259	0.291	0.189	0.622	0.369	0.303	0.362	0.319
Figure by (1)

1.

Wang C, Zhong B, Zhang Z, Chaudhary N, Misra S, Tang J. PDB-Struct: A Comprehensive Benchmark for Structure-based Protein Design. 2023; Available from: https://arxiv.org/abs/2312.00080