Summary
Protein abundance is inversely correlated with its propensity to form nonfunctional protein-protein interactions (1). This is more evident in E. coli than S. cerivisiae and H. sapiens. Note that this analysis was carried out in well-folded proteins in the PDB. This may be one of the constraints on high-abundance proteins that causes low-abundance proteins to evolve faster.
1.
Levy ED, De S, Teichmann SA. Cellular crowding imposes global constraints on the chemistry and evolution of proteomes. Proceedings of the National Academy of Sciences. 2012;109(50):20461–6. Available from: https://doi.org/10.1073/pnas.1209312109