Summary
Protein structure prediction and design metrics (pLDDT, perplexity, sequence homology) do not correlate with probability of expression (1).
Figures
See also
- Sequence- and structure-derived ML quality metrics from ML do not correlate with each other
- Protein structure prediction and design confidence metrics do not correlate with binding affinity
1.
Yang KK, Alamdari S, Lee AJ, Kaymak-Loveless K, Char S, Brixi G, et al. The Dayhoff Atlas: scaling sequence diversity for improved protein generation. openRxiv; 2025. Available from: https://doi.org/10.1101/2025.07.21.665991