Summary
Proteins in halophilic organisms are more negatively charged, and consequently have a much lower isoelectric point than proteins in most model organisms (mentioned by (1)). These can make them attractive starting points for laboratory evolution.
See also
1.
Ding F, Steinhardt J. Protein language models are biased by unequal sequence sampling across the tree of life. openRxiv; 2024. Available from: https://doi.org/10.1101/2024.03.07.584001