Summary
Ribosomes penalize the unfolded states of proteins during protein folding in a sequence-independent manner (1). This is achieved by physically expanding the conformational ensemble such that it is less spherical, reducing the entropic penalty to protein folding by 2 kcal/mol at 298 K and the SASA penalty by 11±4 kcal/mol.
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Ref (1)
1.
Streit JO, Bukvin IV, Chan SHS, Bashir S, Woodburn LF, Włodarski T, et al. The ribosome lowers the entropic penalty of protein folding. Nature. 2024;633(8028):232–9. Available from: https://doi.org/10.1038/s41586-024-07784-4