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Protein folding

Protein folding

Created Apr 10, 2026Modified Apr 20, 2026

Not to be confused with protein structure prediction

Protein folding is the process by which an amino acid polypeptide self-organizes into a 3D structure.

Prediction

no-h

Structure prediction

10 items with this tag.

Apr 21, 2026
Diffusion-based structure prediction can be steered by modifying the conditioning embeddings rather than the latent space, and such embeddings can be used for subsequent iterations
Apr 21, 2026
Diffusion-based protein structure prediction methods double as energy methods comparable to traditional force fields
- diffusion-models/structure-prediction
- protein-folding/structure-prediction
Apr 21, 2026
Diffusion-based structure prediction can sometimes model conformational ensembles
Apr 21, 2026
Enhanced diffusion with metadynamics-like potentials can sometimes convergence slower than unbiased diffusion
Apr 21, 2026
Ensembles can be modeled by structure prediction NNs using experimental data via guidance sampling
Apr 21, 2026
Protein backbone design diffusion models can be repurposed for fitting structures into electron density
Apr 21, 2026
Flow matching and diffusion perform comparably for biomolecular structure prediction
Apr 21, 2026
Biomolecular diffusion models cannot reproduce the equilibrium dynamics of the simulations they are trained on
Apr 21, 2026
Confidence metrics for diffusion-based structure prediction methods can be improved with minimal changes to conditioning representations
Apr 21, 2026
Guidance potentials can be added to diffusion-based structure prediction for enhanced sampling of protein conformations

Unfolding

16 items with this tag.

May 06, 2026
CDR1 and CDR2 contribute more to antibody stability than CDR3
- cdrh3
- protein-folding/unfolding
Apr 21, 2026
Cooperative unfolding is not correlated with overall protein stability across proteins with the same fold
- thermostability
- protein-folding/unfolding
Apr 21, 2026
De novo designed proteins have multiphasic folding pathways
- protein-folding/unfolding
Apr 21, 2026
Differences in thermostability of structurally similar proteins are due to differences in unfolding rates
- thermostability/determinants
- protein-folding/unfolding
Apr 21, 2026
Effect of missense mutations on folding is greater than on binding
- protein-folding/unfolding
Apr 21, 2026
High-stability substructures fold first
- thermostability
- protein-folding/unfolding
Apr 21, 2026
N- and C-termini that are close in space are correlated with correct protein folding
- protein-folding/unfolding
Apr 21, 2026
Proline content correlates with high unfolding cooperativity but not overall stability
- thermostability
- protein-folding/unfolding
Apr 21, 2026
Protein folding duration scales with the inverse square root of its length
- protein-folding/unfolding
Apr 21, 2026
Proteins with greater folding stability have more intermediate partially unfolded states
Apr 21, 2026
Ribosomes penalize the unfolded states of proteins
Apr 21, 2026
Unfolding cooperativity is more difficult to predict than protein stability
- thermostability
- protein-folding/unfolding
Apr 21, 2026
Compactness is positively correlated with unfolding cooperativity but negatively correlated with stability
- thermostability
- protein-folding/unfolding
Apr 21, 2026
Most proteins have a single folding route
- protein-folding/unfolding
Apr 21, 2026
Protein denaturation cooperativity varies depending on whether it is thermally, chemically, or pressure induced
- thermostability
- protein-folding/unfolding
Apr 21, 2026
Small energy barriers separate unfolded and folded states of small fast-folding proteins

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