Ribulose 1,5-bisphosphate carboxylase (also called Rubisco) is an enzyme that is used by plants and cyanobacteria to fix CO2. It a common target for directed evolution due to its intrinsically low catalytic activity (1).
1.
de Pins B, Malbranke C, Jabłońska J, Shmuel A, Sharon I, Bitbol A-F, et al. Rubisco is slow across the tree of life. Proceedings of the National Academy of Sciences. 2025;122(47). Available from: https://doi.org/10.1073/pnas.2501433122