Summary
Short insertions are more common in natural genomes (1).
Details
From (1)
We show that rates of indel mutagenesis are highly heterogeneous, with 43%–48% of indels occurring in 4.03% of the genome, whereas in the remaining 96% their prevalence is 16 times lower than SNPs. Polymerase slippage can explain upwards of three-fourths of all indels, with the remainder being mostly simple deletions in complex sequence.
See also
1.
Montgomery SB, Goode DL, Kvikstad E, Albers CA, Zhang ZD, Mu XJ, et al. The origin, evolution, and functional impact of short insertion–deletion variants identified in 179 human genomes. Genome Research. 2013;23(5):749–61. Available from: https://doi.org/10.1101/gr.148718.112