Summary
About two thirds (68.8%) of deletion mutations not tolerated by proteins, whereas tolerance to insertion mutations varied across proteins (more tolerated in six of nine proteins tested by authors; (1)). This is also true of out-of-frame insertions and deletions, which introduce a substitution. Tolerance here is measured in abundance (see Protein stability, expression, and resistance to proteolysis are correlated)
1.
Topolska M, Beltran A, Lehner B. Deep indel mutagenesis reveals the impact of amino acid insertions and deletions on protein stability and function. Nature Communications. 2025;16(1). Available from: https://doi.org/10.1038/s41467-025-57510-5