Summary
Sodium-coupled and proton-coupled Secondary-active-transporters share a cation-independent ancestor (1). This was determined using cryo-EM and Ancestral sequence reconstruction and is an example of how functional divergence evolves in unusual ways.
Figures
Figure 4 from (1)
See also
1.
Reddy KD, Rasool B, Akher FB, Kutlešić N, Pant S, Boudker O. Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters. Nature Structural & Molecular Biology. 2025;32(12):2564–74. Available from: https://doi.org/10.1038/s41594-025-01652-z