Quartz 4

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Ancestry

Created Sep 26, 2026Modified Sep 07, 2026

Ancestral reconstruction, consensus sequences, historical inference, and their uses in engineering.

14 items with this tag.

Apr 21, 2026
Ancestral enzymes are not always more generalist
- evolution/ancestry
- biophysics/catalysis
Apr 21, 2026
Ancestral sequence reconstruction outperforms generative ML methods on functional enzyme design
Apr 21, 2026
Ancestrally reconstructed enzymes show greater expression than extant enzymes
- evolution/ancestry
- design/developability
Apr 21, 2026
Ancestrally reconstructed sequences are more thermostable than extant sequences
- evolution/ancestry
- biophysics/stability
Apr 21, 2026
Equilibrium dynamics of fold switching proteins change during evolution
- evolution/ancestry
- biophysics/dynamics
Apr 21, 2026
Evolutionary pathway between two folds identified using AlphaFold2 and ancestral sequence reconstruction
- evolution/ancestry
- biophysics/dynamics
Apr 21, 2026
Including sequences from multiplexed ancestral sequence reconstruction improves PLM training
Apr 21, 2026
Sodium- and proton-coupled transporters share a cation-independent ancestor
- evolution/ancestry
- biophysics/dynamics
Apr 21, 2026
The activity profiles of ancestrally reconstructed enzymes are more difficult to predict than extant or ML-generated enzymes
Apr 21, 2026
Consensus sequence thermostabilities and activities are sensitive to breadth of sequences used for calculation
- evolution/ancestry
- design/enzymes
Apr 21, 2026
Consensus sequences are less thermostable than ancestrally reconstructed sequences
- evolution/ancestry
- biophysics/stability
Apr 21, 2026
Consensus sequences can show greater expression than extant sequences
- evolution/ancestry
- design/developability
Apr 21, 2026
Incorporating ancestral sequences during PLM training improves performance in downstream tasks
Apr 20, 2026
Ancestral sequence reconstruction
- evolution/ancestry

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