Summary
The AlphaFold2 and ESMFold databases can be mined for alternate conformations (1,2). This is because different sub-families of sequences yield different conformational states.
1.
Wayment-Steele HK, Ojoawo A, Otten R, Apitz JM, Pitsawong W, Hömberger M, et al. Predicting multiple conformations via sequence clustering and AlphaFold2. Nature. 2023;625(7996):832–9. Available from: https://doi.org/10.1038/s41586-023-06832-9
2.
Schwartz AC, Stein RA, Gil-Iturbe E, Quick M, Mchaourab HS. Alternating Access of a Neurotransmitter:Sodium Symporter Bacterial Homolog Determined from AlphaFold2 Ensembles and DEER Spectroscopy. openRxiv; 2024. Available from: https://doi.org/10.1101/2024.04.08.587957