Summary
Proteins with high thermostability have more small aliphatic amino acids that allow more flexible contacts, leading to slower unfolding (1). This was observed using MD simulations.
1.
Cea PA, Pérez M, Herrera SM, Muñoz SM, Fuentes-Ugarte N, Coche-Miranda J, et al. Deciphering Structural Traits for Thermal and Kinetic Stability across Protein Family Evolution through Ancestral Sequence Reconstruction. Molecular Biology and Evolution. 2024;41(7). Available from: https://doi.org/10.1093/molbev/msae127