Summary
Interface PAE is anticorrelated with the number of H-bonds in PPIs(1). This is consistent with these confidence metrics learning some biophysical determinants of binding or stability.
Figures
Ref(1)
1.
Didi K, Alamdari S, Lu AX, Wittmann B, Johnston KE, Amini AP, et al. FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications. openRxiv; 2026. Available from: https://doi.org/10.64898/2026.02.23.707496