Summary
Affinity maturation causes antibody-antigen interfaces to more closely resemble those of generic protein-protein interactions (1).
1.
Burkovitz A, Sela‐Culang I, Ofran Y. Large‐scale analysis of somatic hypermutations in antibodies reveals which structural regions, positions and amino acids are modified to improve affinity. The FEBS Journal. 2013;281(1):306–19. Available from: https://doi.org/10.1111/febs.12597