Summary
All-atom protein structure prediction methods are unable to accurately model protein-protein interactions with large buried surface areas (1).
Figures

Ref (1)
1.
Liao Y, Zhu J, Xie J, Lai L, Pei J. Comparative assessment of co-folding methods for molecular glue ternary structure prediction. openRxiv; 2025. Available from: https://doi.org/10.1101/2025.05.25.655997