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Protein ligand co folding

Protein-ligand co-folding

Created Apr 10, 2026Modified Apr 21, 2026

Protein-ligand co-folding refers to methods that can predict the structures of proteins with small molecules or other macromolecules such as RNA.

Methods

  • AlphaFold3
  • RosettaFold-AllAtom
  • Chai-1
  • Boltz-1
  • NeuralPlexer
  • Protenix

Graph View

Backlinks

  • AF3-generation methods can be substantially shrunk without sacrificing prediction quality, except on PPIs
  • All-atom protein structure prediction methods are unable to model PPIs with large buried surface areas
  • All-atom structure prediction of RNA is driven by memorization
  • Memorization in protein structure prediction

Created with Quartz v4.5.2 © 2026

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