AlphaFold2 predicts ground states more often

Summary

AlphaFold2 predicts ground states more often (Chakravarty and (1)). In a benchmark of Fold-switching proteins, AlphaFold2 predicted the ground state 70% of the time, vs the excited state 30% of the time.

See also

• AlphaFold2 predicts the holo form of proteins in most cases

1.

Chakravarty D, Porter LL. AlphaFold2 fails to predict protein fold switching. Protein Science. 2022;31(6). Available from: https://doi.org/10.1002/pro.4353