Fold-switching proteins, also called metamorphic proteins, are proteins that can adopt multiple folds, such as by changing secondary structure or rearranging their substructures.
Ref (1)
Notes
Tokuriki and Tawfik (2) discuss additional examples.
1.
Dishman AF, Tyler RC, Fox JC, Kleist AB, Prehoda KE, Babu MM, et al. Evolution of fold switching in a metamorphic protein. Science. 2021;371(6524):86–90. Available from: https://doi.org/10.1126/science.abd8700
2.
Tokuriki N, Tawfik DS. Protein Dynamism and Evolvability. Science. 2009;324(5924):203–7. Available from: https://doi.org/10.1126/science.1169375