AlphaFold3 performs comparably to AlphaFold2 when predicting multiple conformations of fold-switching proteins

Summary

AlphaFold3 performs comparably to AlphaFold2 (specifically MSA clustering and sequence masking) when predicting the structures of fold-switching proteins (1).

Figures

Ref (1)

See also

• AlphaFold2 predicts ground states more often

1.

Chakravarty D, Schafer JW, Chen EA, Thole JF, Ronish LA, Lee M, et al. AlphaFold predictions of fold-switched conformations are driven by structure memorization. Nature Communications. 2024;15(1). Available from: https://doi.org/10.1038/s41467-024-51801-z