Summary
Antibody developability predictions are stable to single point mutations (1). Mutations to framework regions were found to have the greatest variance in potential impact, whereas mutations to CDRs were not.
Figures
Ref (1)
See also
1.
Bashour H, Smorodina E, Pariset M, Zhong J, Akbar R, Chernigovskaya M, et al. Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability. Communications Biology. 2024;7(1). Available from: https://doi.org/10.1038/s42003-024-06561-3