Summary
(Antibody) sequence similarity is not correlated with (developability) similarity (1). Most of the sequence variation is in CDRH3, whereas framework residues had an outside impact on actual effects.
1.
Bashour H, Smorodina E, Pariset M, Zhong J, Akbar R, Chernigovskaya M, et al. Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability. Communications Biology. 2024;7(1). Available from: https://doi.org/10.1038/s42003-024-06561-3