Antibody thermostability is not correlated with polyreactivity

Summary

Fab thermostability is not correlated with polyreactivity (1).

Details

In a panel of B cell-derived mAbs, apparent melting temperature and PSR score had $R^2=0.0083$.

Figures

Figure S3C from (1)

See also

• Antibody thermostability decreases during affinity maturation, up to a threshold
• Somatic hypermutation correlates with lower polyreactivity

1.

Shehata L, Maurer DP, Wec AZ, Lilov A, Champney E, Sun T, et al. Affinity Maturation Enhances Antibody Specificity but Compromises Conformational Stability. Cell Reports. 2019;28(13):3300-3308.e4. Available from: https://doi.org/10.1016/j.celrep.2019.08.056