Summary
The thermostability of antibodies decreases during affinity maturation, up to a specific threshold (1). This threshold is usually reached within a few mutations. Likewise, antibody thermostability can be increased by introducing germline mutations (1).
Figures
Figure 3C from (1)
See also
1.
Shehata L, Maurer DP, Wec AZ, Lilov A, Champney E, Sun T, et al. Affinity Maturation Enhances Antibody Specificity but Compromises Conformational Stability. Cell Reports. 2019;28(13):3300-3308.e4. Available from: https://doi.org/10.1016/j.celrep.2019.08.056