Summary
Somatic hypermutation is associated with lower polyreactivity (1).
Figures
Figure 2C-E from (1)
See also
- Antibody thermostability decreases during affinity maturation, up to a threshold
- Antibodies from naive B cells are more polyreactive
1.
Shehata L, Maurer DP, Wec AZ, Lilov A, Champney E, Sun T, et al. Affinity Maturation Enhances Antibody Specificity but Compromises Conformational Stability. Cell Reports. 2019;28(13):3300-3308.e4. Available from: https://doi.org/10.1016/j.celrep.2019.08.056