Summary
CDRH3 mediates pairing between heavy and light chains of antibodies by making contacts with the framework region of the opposite chain (1).
See also
1.
Dudzic P, Chomicz D, Bielska W, Jaszczyszyn I, Zieliński M, Janusz B, et al. Conserved heavy/light contacts and germline preferences revealed by a large-scale analysis of natively paired human antibody sequences and structural data. Communications Biology. 2025;8(1). Available from: https://doi.org/10.1038/s42003-025-08388-y