Summary
Light chain coherence refers to the high probability that functional antibodies expressed by memory B cells with the same CDRH3 loop and V-gene also share the same light chain (1). The finding holds across pairs of B-cells with the same heavy V-gene and CDRH3 length from different donors, and across different datasets collected at different times.
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Ref (1)
See also
1.
Jaffe DB, Shahi P, Adams BA, Chrisman AM, Finnegan PM, Raman N, et al. Functional antibodies exhibit light chain coherence. Nature. 2022;611(7935):352–7. Available from: https://doi.org/10.1038/s41586-022-05371-z