Summary
CDRH3 has the most antigen contacts of any CDR. This is consistent with its hypervariability due to somatic hypermutation (Kunik and (1,2)).
Figures
Ref Kunik and (1)
1.
Kunik V, Ofran Y. The indistinguishability of epitopes from protein surface is explained by the distinct binding preferences of each of the six antigen-binding loops. Protein Engineering, Design and Selection. 2013;26(10):599–609. Available from: https://doi.org/10.1093/protein/gzt027
2.
Fernández-Quintero ML, Loeffler JR, Bacher LM, Waibl F, Seidler CA, Liedl KR. Local and Global Rigidification Upon Antibody Affinity Maturation. Frontiers in Molecular Biosciences. 2020;7. Available from: https://doi.org/10.3389/fmolb.2020.00182