Summary
Identical CDRH3 is necessary but insufficient to guarantee binding to the same epitope (D’(1)). This was determined after observing that many antibodies with different combinations of V, D, and J genes but the same CDRH3 are nonetheless unable to bind to the same target.
See also
- Computational antibody design is more reliable when HCDR3 is held fixed
- Computational ranking of HCDR3 clones can underperform random selection
1.
D’Angelo S, Ferrara F, Naranjo L, Erasmus MF, Hraber P, Bradbury ARM. Many Routes to an Antibody Heavy-Chain CDR3: Necessary, Yet Insufficient, for Specific Binding. Frontiers in Immunology. 2018;9. Available from: https://doi.org/10.3389/fimmu.2018.00395