Summary
Identical CDRH3 is necessary but insufficient to guarantee binding to the same epitope (D’(1)). This was determined after observing that many antibodies with different combinations of V, D, and J genes but the same CDRH3 are nonetheless unable to bind to the same target.
1.
D’Angelo S, Ferrara F, Naranjo L, Erasmus MF, Hraber P, Bradbury ARM. Many Routes to an Antibody Heavy-Chain CDR3: Necessary, Yet Insufficient, for Specific Binding. Frontiers in Immunology. 2018;9. Available from: https://doi.org/10.3389/fimmu.2018.00395